Countless biological processes occur at or near interfaces, including cell-cell and cell-surface adhesion, protein synthesis and secretion, and the transport of cellular nutrients and wastes. These processes rely on a complex interplay of molecular-level interactions for their proper function. Because this interplay is often disrupted by the presence of foreign surfaces, a major challenge facing biomedical engineers is to more deeply understand molecular-level interfacial processes so that the rational design of biocompatible materials, tissue scaffolds, artificial organs, and drug delivery vehicles can be achieved. The goal of this symposium is to bring together scientists and engineers applying surface science techniques to systems of biological importance. Our discussion will include both advances in instrumentation and novel insights into interfacial phenomena in biological systems.